Aberrant Expression and Glycosylation of Mucins in Gastric Mucosal Disease.
10.3881/j.issn.1000-503X.12945
- Author:
Long ZOU
1
;
Ai-Ming YANG
1
Author Information
1. Department of Gastroenterology,PUMC Hospital,CAMS and PUMC,Beijing 100730, China.
- Publication Type:Review
- Keywords:
chronic atrophic gastritis;
dysplasia;
gastric cancer;
glycosylation;
intestinal metastasis;
mucins
- MeSH:
Gastric Mucosa/pathology*;
Glycosylation;
Helicobacter Infections/pathology*;
Helicobacter pylori/metabolism*;
Humans;
Mucins/metabolism*;
Stomach Neoplasms/pathology*
- From:
Acta Academiae Medicinae Sinicae
2022;44(2):294-298
- CountryChina
- Language:Chinese
-
Abstract:
Mucins,a family of heavily glycosylated proteins,present mainly in epithelial cells.They function as essential barriers for epithelium and play important roles in cellular physiological processes.Aberrant expression and glycosylation of mucins in gastric epithelium occur at pathological conditions,such as Helicobacter pylori infection,chronic atrophic gastritis,intestinal metastasis,dysplasia,and gastric cancer.This review addresses the major roles played by mucins and associated O-glycan structures in normal gastric epithelium.Further,we expound the alterations of expression patterns and glycan signatures of mucins at those pathological conditions.
