Progress in the Role of Mechanical Stimulus in Cardiac Development.
10.3881/j.issn.1000-503X.12954
- Author:
Ming-Hui XIE
1
;
Wei-Hua QIAO
1
;
Hong CAO
1
;
Jia-Wei SHI
1
;
Nian-Guo DONG
1
Author Information
1. Department of Cardiovascular Surgery,Union Hospital,Tongji Medical College, Huazhong University of Science and Technology,Wuhan 430022,China.
- Publication Type:Review
- Keywords:
cardiac development;
congenital heart diseases;
hydromechanics;
mechanical sensor;
mechanical transduction
- MeSH:
Animals;
Heart/embryology*;
Humans;
Mechanotransduction, Cellular;
Myocytes, Cardiac/physiology*;
Vascular Endothelial Growth Factor A/metabolism*
- From:
Acta Academiae Medicinae Sinicae
2022;44(1):164-172
- CountryChina
- Language:Chinese
-
Abstract:
Mechanical stimulus is critical to cardiovascular development during embryogenesis period.The mechanoreceptors of endocardial cells and cardiac myocytes may sense mechanical signals and initiate signal transduction that induce gene expression at a cellular level,and then translate molecular-level events into tissue-level deformations,thus guiding embryo development.This review summarizes the regulatory roles of mechanical signals in the early cardiac development including the formation of heart tube,looping,valve and septal morphogenesis,ventricular development and maturation.Further,we discuss the potential mechanical transduction mechanisms of platelet endothelial cell adhesion molecule 1-vascular endothelial-cadherin-vascular endothelial growth factor receptor 2 complex,primary cilia,ion channels,and other mechanical sensors that affect some cardiac malformations.
