Advances in N-methyl-D-aspartate Receptor Signaling Pathway and Mechanism of the Pathway-mediated Apoptosis.
10.3881/j.issn.1000-503X.14062
- Author:
Yi-Xiao HAN
1
;
Ya-Zhu HOU
1
;
Hai-Feng YAN
1
;
Shuai WANG
1
;
Xian-Liang WANG
1
;
Jing-Yuan MAO
1
Author Information
1. Department of Cardiology,First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin 300381,China.
- Publication Type:Review
- Keywords:
N-methyl-D-aspartate receptor;
apoptosis;
signaling pathways
- MeSH:
Apoptosis;
Humans;
Mitogen-Activated Protein Kinases/metabolism*;
Reactive Oxygen Species/metabolism*;
Receptors, N-Methyl-D-Aspartate/metabolism*;
Signal Transduction
- From:
Acta Academiae Medicinae Sinicae
2022;44(1):149-157
- CountryChina
- Language:Chinese
-
Abstract:
N-methyl-D-aspartate receptor (NMDAR),an important ionic glutamate receptor and a ligand and voltage-gated ion channel characterized by complex composition and functions and wide distribution,plays a key role in the pathological and physiological process of diseases or stress states.NMDAR can mediate apoptosis through different pathways such as mitochondrial and endoplasmic reticulum damage,production of reactive oxygen species and peroxynitrite,and activation of mitogen-activated protein kinase and calpain.This paper reviews the structure,distribution,and biological characteristics of NMDAR and the mechanisms of NMDAR-mediated apoptosis.
