Molecular Mechanism of Aurora Kinase A Regulating the Meiosis of Oocyte.
10.3881/j.issn.1000-503X.13811
- Author:
Feng LIU
1
;
Bo YAO
1
;
Xiao-Long MO
1
;
Qiong-You LIU
1
;
Yan-Ping REN
1
Author Information
1. Department of Histology and Embryology,School of Preclinical Medicine,Zunyi Medical University,Zunyi,Guizhou 563000,China.
- Publication Type:Review
- Keywords:
Aurora kinase A;
kinetochore-microtubule attachment;
meiosis;
microtubule-organizing center;
oocyte;
spindle assembly
- MeSH:
Aurora Kinase A/genetics*;
Cell Cycle Proteins/genetics*;
Chromosome Segregation;
Humans;
Meiosis;
Oocytes
- From:
Acta Academiae Medicinae Sinicae
2022;44(1):142-148
- CountryChina
- Language:Chinese
-
Abstract:
Aurora kinase A (AURKA),a family member of aurora kinases,is involved in mitotic entry,maturation and separation of centrosome,assembly and stabilization of bipolar spindle,and condensation and separation of chromosome.Studies have demonstrated that AURKA plays a similar role in meiosis,while the specific mechanism and the similarities and differences in its role between meiosis and mitosis remain unclear.Therefore,we reviewed the studies about the localization and activation of AURKA in oocyte meiosis,and compared the role of AURKA in regulating spindle formation,activating spindle assembly checkpoint,and correcting the kinetochore-microtubule attachment between the meiosis of oocytes and the mitosis of somatic cells.This review will lay a theoretical foundation for revealing the mechanism of AURKA in the regulation of cell division and for the clinical research related to cancer and reproduction.
