Clinical Characteristics and Treatment Outcome of Pseudomonas Peritoneal Dialysis-associated Peritonitis.
10.3881/j.issn.1000-503X.14016
- Author:
Ce NI
1
;
Li-Ming YANG
2
;
Xue-Yan ZHU
3
;
Xiao-Xuan ZHANG
4
;
Wen-Hua ZHOU
1
;
Shun-Yun XIE
1
;
Meng-Yuan YU
1
;
Xiao-Hua ZHUANG
1
;
Ping LUO
1
;
Wen-Peng CUI
1
Author Information
1. Department of Nephrology,the Second Hospital of Jilin University,Changchun 130041,China.
2. Department of Nephrology,the Easrern Division of the First Hospital of Jilin University,Changchun 130031,China.
3. Department of Nephrology,Jilin Central Hospital,Jilin,Jilin 132011,China.
4. Department of Nephrology,Jilin First Automobile Work General Hospital,Changchun 130011,China.
- Publication Type:Journal Article
- Keywords:
peritoneal dialysis;
peritonitis
- MeSH:
Humans;
Peritoneal Dialysis/adverse effects*;
Peritonitis/etiology*;
Pseudomonas;
Retrospective Studies;
Treatment Outcome
- From:
Acta Academiae Medicinae Sinicae
2022;44(1):45-52
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical characteristics and treatment of Pseudomonas peritoneal dialysis-associated peritonitis(PsP). Methods The data of patients receiving peritoneal dialysis in four tertiary hospitals in Jilin province from 2015 to 2019 were retrospectively analyzed.According to the etiological classification,the patients with peritoneal dialysis-associated peritonitis(PDAP)were classified into PsP group and non-PsP group.The incidence of PsP was calculated,and the clinical characteristics and treatment outcomes of the two groups were compared.Kaplan-Meier method was used to draw the survival curve,and Cox regression was performed to analyze the risk factors affecting the technical failure of PsP.The treatment options of Pseudomonas aeruginosa-caused PDAP and the drug sensitivity of PsP were summarized. Results A total of 1530 peritoneal dialysis patients with complete data were included in this study,among which 439 patients had 664 times of PDAP.The incidence of PsP was 0.007 episodes/patient-year.PsP group had higher proportion of refractory peritonitis(41.38% vs.19.69%,P=0.005),lower cure rate(55.17% vs.80.79%, P=0.001),and higher extubation rate(24.14% vs.7.09%,P=0.003)than non-PsP group.The technical survival rate of PsP group was lower than that of non-PsP group(P<0.001).Multivariate Cox regression analysis showed that Pseudomonas aeruginosa was an independent risk factor for technical failure in patients with PsP(HR=9.020,95%CI=1.141-71.279,P=0.037).Pseudomonas was highly sensitive to amikacin,meropenem,and piperacillin-tazobactam while highly resistant to compound sulfamethoxazole,cefazolin,and ampicillin. Conclusion The treatment outcome of PsP is worse than that of non-PsP,and Pseudomonas aeruginosa is an independent risk factor for technical failure of PsP.
