Advances in receptor-mediated resistance mechanisms of Lepidopteran insects to <i>Bacillus thuringiensis</i> toxin.

Leilei Liu; Peiwen XU; Kaiyu Liu; Wei Wei; Zhongshen Chang; Dahui Cheng

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Advances in receptor-mediated resistance mechanisms of Lepidopteran insects to Bacillus thuringiensis toxin.

Author: Leilei LIU ¹ ; Peiwen XU ¹ ; Kaiyu LIU ² ; Wei WEI ¹ ; Zhongshen CHANG ¹ ; Dahui CHENG ¹
Author Information

1. Center of Applied Biotechnology, School of Life Sciences and Technology, Wuhan University of Bioengineering, Wuhan 430415, Hubei, China.
2. Institute of Entomology, School of Life Sciences, Central China Normal University, Wuhan 430079, Hubei, China.
Publication Type:Review
Keywords: Bacillus thuringiensis; Lepidopteran insects; resistance; toxin receptors
MeSH: Animals; Bacillus thuringiensis/genetics*; Bacillus thuringiensis Toxins; Bacterial Proteins/metabolism*; Endotoxins/metabolism*; Hemolysin Proteins/metabolism*; Insecta/metabolism*; Insecticide Resistance/genetics*; Insecticides/pharmacology*; Pest Control, Biological
From: Chinese Journal of Biotechnology 2022;38(5):1809-1823
CountryChina
Language:Chinese
Abstract: Bacillus thuringiensis is widely used as an insecticide which is safe and environmentally friendly to humans and animals. One of the important insecticidal mechanisms is the binding of Bt toxins to specific toxin receptors in insect midgut and forming a toxin perforation which eventually leads to insect death. The resistance of target pests to Bt toxins is an important factor hampering the long-term effective cultivation of Bt crops and the continuous use of Bt toxins. This review summarizes the mechanism of insect resistance to Bt toxins from the perspective of important Bt toxin receptors in midgut cells of Lepidopteran insects, which may facilitate the in-depth study of Bt resistance mechanism and pest control.