Advances in several important antimicrobial lipopeptids from <i>Bacillus</i> spp.

Daoming LI; Ying Wang; Chao Chen; Mingbai Zeng; Qianru LI; Qingyun Jia; Xiuli Liu; Yongyue Hou; Chengming Fan; Yuhong Chen; Zanmin HU

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Advances in several important antimicrobial lipopeptids from Bacillus spp.

Author: Daoming LI ¹ ; Ying WANG ² ; Chao CHEN ² ; Mingbai ZENG ² ; Qianru LI ² ; Qingyun JIA ² ; Xiuli LIU ³ ; Yongyue HOU ³ ; Chengming FAN ² ; Yuhong CHEN ² ; Zanmin HU ²
Author Information

1. Comprehensive Service Center of Agriculture and Rural Areas of Bincheng District, Binzhou 256600, Shandong, China.
2. The Innovative Academy of Seed Design, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.
3. Veterinary Research Institute, Inner Mongolia Academy of Agriculture and Animal Husbandry Sciences, Hohhot 010031, Inner Mongolia, China.
Publication Type:Journal Article
Keywords: Bacillus subtilis; biosynthetic regulation; function; lipopeptides; structure
MeSH: Anti-Bacterial Agents; Anti-Infective Agents/pharmacology*; Bacillus; Bacillus subtilis; Lipopeptides/pharmacology*; Peptides, Cyclic/pharmacology*
From: Chinese Journal of Biotechnology 2022;38(5):1768-1783
CountryChina
Language:Chinese
Abstract: Bacillus spp. are probiotics and can secrete a variety of natural antimicrobiol active substances, of which lipopeptides are an important class. Up to now, about 90 lipopeptides have been identified, and most of them are cyclic lipopeptides. surfactin, iturin, fengycin, bacillomycin and polymyxins are widely studied, and the first three have huge potential for application due to their properties of surfactants and anti-fungal, anti-bacterial, anti-viral, anti-tumor and anti-inflammatory functions. In this paper, the research progress in the structure, function, synthesis regulation, separation, purification and production of surfactin, iturin and fengycin was reviewed. Synthetic biology is a vital means to increase the yield of lipopeptides, and in the future, lipopeptides can be used in crop cultivation, animal farming, food, medicine and petroleum industries as well as environmental protection. Future research should be strengthened on the discovery of new lipopeptides, synthesis of high-activity lipopeptides, economical production of lipopeptides on a large scale and their safety evaluation.