Using plant extracts and their active ingredients to inhibit bacterial biofilms.

Peng Cheng; Jing Xiong; Hui LI; Shiyuan Wang; Yang Zhang; Cui Mei; Xueqing WU; Yuzhang HE; Hongwei Chen

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Using plant extracts and their active ingredients to inhibit bacterial biofilms.

Author: Peng CHENG ¹ ; Jing XIONG ¹ ; Hui LI ¹ ; Shiyuan WANG ¹ ; Yang ZHANG ¹ ; Cui MEI ¹ ; Xueqing WU ² ; Yuzhang HE ³ ; Hongwei CHEN ¹
Author Information

1. Immunology Research Center, Medical Research Institute, Southwest University, Chongqing 402460, China.
2. Department of Infectious Diseases, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310000, Zhejiang, China.
3. College of Veterinary Medicine, Southwest University, Chongqing 402460, China.
Publication Type:Review
Keywords: bacterial biofilm; mechanism; plant extracts; quorum sensing
MeSH: Anti-Bacterial Agents/pharmacology*; Bacteria; Biofilms; Humans; Plant Extracts/pharmacology*; Quorum Sensing
From: Chinese Journal of Biotechnology 2022;38(5):1753-1767
CountryChina
Language:Chinese
Abstract: Numerous studies have reported that the resistance of biofilm bacteria to antibiotics can be up to 10-1 000 fold higher than that of planktonic bacteria. Bacterial biofilms are reported to be responsible for more than 80% of human microbial infection, posing great challenges to the healthcare sector. Many studies have reported that plant extracts and their active ingredients can inhibit the formation and development of bacterial biofilms, including reducing biofilm biomass and the number of viable bacteria in biofilms, as well as eradicating mature biofilms. This review summarized the plant extracts and their active ingredients that are inhibitory to bacterial biofilms, and analyzed the underpinning mechanisms. This review may serve as a reference for the development of plant drugs to prevent and treat biofilm infections.