Recent progress in ergothioneine biosynthesis: a review.

Author: Qi LIU ¹ ; Yufeng MAO ¹ ; Xiaoping LIAO ¹ ; Jiahao LUO ¹ ; Hongwu MA ¹ ; Wenxia JIANG ¹
Author Information

1. Tianjin Key Laboratory for Industrial Biological Systems and Bioprocessing Engineering, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China.
Publication Type:Review
Keywords: biosynthesis; ergothioneine; fermentation engineering; metabolic engineering; natural mushroom
MeSH: Antioxidants; Ergothioneine/metabolism*; Fermentation; Metabolic Engineering
From: Chinese Journal of Biotechnology 2022;38(4):1408-1420
CountryChina
Language:Chinese
Abstract: Ergothioneine is a multifunctional physiological cytoprotector, with broad application in foods, beverage, medicine, cosmetics and so on. Biosynthesis is an increasingly favored method in the production of ergothioneine. This paper summarizes the new progress in the identification of key pathways, the mining of key enzymes, and the development of natural edible mushroom species and high-yield engineering strains for ergothioneine biosynthesis in recent years. Through this review, we aim to reveal the molecular mechanism of ergothioneine biosynthesis and then employ the methods of fermentation engineering, metabolic engineering, and synthetic biology to greatly increase the yield of ergothioneine.