Tolerance engineering regulates stress resistance of microbial cell factory.
- Author:
Li ZHANG
1
;
Jian GAO
1
;
Changqing LIU
1
;
Lina DENG
1
Author Information
- Publication Type:Journal Article
- Keywords: damage repair; evolutionary engineering; microbial cell factory; stress defense; stress resistance; tolerance engineering
- MeSH: Cell Membrane; Metabolic Engineering
- From: Chinese Journal of Biotechnology 2022;38(4):1373-1389
- CountryChina
- Language:Chinese
- Abstract: The production efficiency of microbial cell factory is determined by the growth performance, product synthetic capacity, and stress resistance of the strain. Strengthening the stress resistance is the key point to improve the production efficiency of microbial cell factory. Tolerance engineering is based on the response mechanism of microbial cell factory to resist stress. Specifically, it consolidates the cell wall-cell membrane barrier to enhance the defense against stress, accelerates the stress response to improve the damage repair, and creates tolerance evolutionary tools to screen industrial microorganisms with enhanced robustness. We summarize the regulation strategies and forecast the prospects of tolerance engineering, which plays an important role in the microbial cell factories for sustainable production of natural products and bulk chemicals.
