Production of carboxylic acids by metabolically engineered <i>Yarrowia lipolytica</i>: a review.

Lanxin Rong; Shiqi Liu; Kun Zhu; Jing Kong; Lin Miao; Shuhui Wang; Dongguang Xiao; Aiqun YU

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Production of carboxylic acids by metabolically engineered Yarrowia lipolytica: a review.

Author: Lanxin RONG ¹ ; Shiqi LIU ¹ ; Kun ZHU ¹ ; Jing KONG ¹ ; Lin MIAO ¹ ; Shuhui WANG ¹ ; Dongguang XIAO ¹ ; Aiqun YU ¹
Author Information

1. Key Laboratory of Industrial Fermentation Microbiology of the Ministry of Education, State Key Laboratory of Food Nutrition and Safety, College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China.
Publication Type:Review
Keywords: Yarrowia lipolytica; carboxylic acid; metabolic engineering; non-conventional yeast; synthetic biology
MeSH: Carboxylic Acids/metabolism*; Metabolic Engineering; Synthetic Biology; Yarrowia/metabolism*
From: Chinese Journal of Biotechnology 2022;38(4):1360-1372
CountryChina
Language:Chinese
Abstract: Yarrowia lipolytica is a non-conventional yeast with unique physiological and metabolic characteristics. It is suitable for production of various products due to its natural ability to utilize a variety of inexpensive carbon sources, excellent tolerance to low pH, and strong ability to secrete metabolites. Currently, Y. lipolytica has been demonstrated to produce a wide range of carboxylic acids with high efficiency. This article summarized the progress in engineering Y. lipolytica to produce various carboxylic acids by using metabolic engineering and synthetic biology approaches. The current bottlenecks and solutions for high-level production of carboxylic acids by engineered Y. lipolytica were also discussed, with the aim to provide useful information for relevant studies in this field.