Advances in synthetic biology of CO<sub>2</sub> fixation by heterotrophic microorganisms.

Author: Guipeng HU ¹ ; Wei SONG ¹ ; Cong GAO ² ; Liang GUO ² ; Xiulai CHEN ² ; Liming LIU ²
Author Information

1. School of Pharmaceutical Sciences, Jiangnan University, Wuxi 214122, Jiangsu, China.
2. State Key Laboratory of Food Science & Technology, Jiangnan University, Wuxi 214122, Jiangsu, China.
Publication Type:Review
Keywords: CO; carbon neutral; carbon peaking; metabolic engineering; synthetic biology
MeSH: Carbon Cycle; Carbon Dioxide/metabolism*; Heterotrophic Processes; Humans; Synthetic Biology
From: Chinese Journal of Biotechnology 2022;38(4):1339-1350
CountryChina
Language:Chinese
Abstract: Human activities increase the concentration of atmospheric carbon dioxide (CO₂), which leads to global climate warming. Microbial CO₂ fixation is a promising green approach for carbon neutral. In contrast to autotrophic microorganisms, heterotrophic microorganisms are characterized by fast growth and ease of genetic modification, but the efficiency of CO₂ fixation is still limited. In the past decade, synthetic biology-based enhancement of heterotrophic CO₂ fixation has drawn wide attention, including the optimization of energy supply, modification of carboxylation pathway, and heterotrophic microorganisms-based indirect CO₂ fixation. This review focuses on the research progress in CO₂ fixation by heterotrophic microorganisms, which is expected to serve as a reference for peaking CO₂ emission and achieving carbon neutral by microbial CO₂ fixation.