- Author:
Guipeng HU
1
;
Wei SONG
1
;
Cong GAO
2
;
Liang GUO
2
;
Xiulai CHEN
2
;
Liming LIU
2
Author Information
- Publication Type:Review
- Keywords: CO; carbon neutral; carbon peaking; metabolic engineering; synthetic biology
- MeSH: Carbon Cycle; Carbon Dioxide/metabolism*; Heterotrophic Processes; Humans; Synthetic Biology
- From: Chinese Journal of Biotechnology 2022;38(4):1339-1350
- CountryChina
- Language:Chinese
- Abstract: Human activities increase the concentration of atmospheric carbon dioxide (CO2), which leads to global climate warming. Microbial CO2 fixation is a promising green approach for carbon neutral. In contrast to autotrophic microorganisms, heterotrophic microorganisms are characterized by fast growth and ease of genetic modification, but the efficiency of CO2 fixation is still limited. In the past decade, synthetic biology-based enhancement of heterotrophic CO2 fixation has drawn wide attention, including the optimization of energy supply, modification of carboxylation pathway, and heterotrophic microorganisms-based indirect CO2 fixation. This review focuses on the research progress in CO2 fixation by heterotrophic microorganisms, which is expected to serve as a reference for peaking CO2 emission and achieving carbon neutral by microbial CO2 fixation.