Advances in the biosynthesis of tetrapyrrole compounds.

Author: Fei PAN ¹ ; Yifan YAN ¹ ; Yifan ZHU ¹ ; Yi HU ¹ ; Xiaoqi XU ¹ ; Zheng XU ¹ ; Rui WANG ¹ ; Sha LI ¹ ; Hong XU ¹ ; Zhengshan LUO ¹
Author Information

1. School of Food and Light Industry, Nanjing Tech University, Nanjing 211816, Jiangsu, China.
Publication Type:Journal Article
Keywords: bilin; biosynthesis; chlorophyll; heme; metabolic engineering; synthetic biology; vitamin B12
MeSH: Biomass; Plants/genetics*; Synthetic Biology; Tetrapyrroles
From: Chinese Journal of Biotechnology 2022;38(4):1307-1321
CountryChina
Language:Chinese
Abstract: Tetrapyrrole compounds are a class of compounds with important functions. They exist in living organisms and have been widely used in agriculture, food, medicine, and other fields. The cumbersome process and high cost of chemical synthesis, as well as the shortcomings of unstable quality of animal and plant extraction methods, greatly hampered the industrial production and applications of tetrapyrrole compounds. In recent years, the rapid development of synthetic biology has provided new tools for microorganisms to efficiently synthesize tetrapyrrole compounds from renewable biomass resources. This article summarizes various strategies for the biosynthesis of tetrapyrrole compounds, discusses methods to improve its biosynthesis efficiency and future prospects, with the aim to facilitate the research on biosynthesis of tetrapyrrole compounds.