Advances in the microbial production of the compatible solute ectoine: a review.

Author: Xin ZHANG ¹ ; Zhiwan SHU ¹ ; Yongzhen LI ¹ ; Jiangwa XING ¹ ; Rong WANG ¹ ; Guoping SHEN ¹ ; Derui ZHU ¹
Author Information

1. Research Center of Basic Medical Science, Medical College of Qinghai University, Xining 810016, Qinghai, China.
Publication Type:Review
Keywords: UV mutagenesis; batch fermentation; ectoine; genetic engineering; system metabolism
MeSH: Amino Acids, Diamino/metabolism*; Fermentation
From: Chinese Journal of Biotechnology 2022;38(3):868-881
CountryChina
Language:Chinese
Abstract: Ectoine is an amino acid derivative and an important natural product in halophilic microorganisms. It plays an important role in protecting cells and stabilizing biological macromolecules, and can be widely used in biomedical fields such as drug preparation adjuvants, organ transplantation and preservation, skin wound repair and cosmetics. Due to the medical value and commercial market demand of ectoine, this article summarized the recent advances in the microbial production of ectoine, including the mutation and breeding of hyper-producing strains, construction of genetically and metabolically engineered strains, optimization of fermentation processes, and extraction and purification processes. The application of multi-omics technologies and computational biology to develop an ectoine producing cell factory was prospected, with the aim to provide a reference for ectoine overproduction.