- Author:
Bowen DENG
1
;
Siyi GAO
1
;
Boyi XIAO
1
;
Yulong WU
1
;
Hao SUN
1
;
Lianghua WANG
1
;
Mingjuan SUN
1
Author Information
- Publication Type:Review
- Keywords: aptamer; computer-aided screening; exponentially enriched ligand system evolution; molecular docking; sequence evaluation; structural analysis
- MeSH: Aptamers, Nucleotide; Computers; Molecular Docking Simulation; SELEX Aptamer Technique/methods*
- From: Chinese Journal of Biotechnology 2022;38(2):678-690
- CountryChina
- Language:Chinese
- Abstract: The computer information technology that has penetrated into every aspect of our lives, can not only assist the screening of drugs, but also simulate the effect of drugs. At present, computer-aided technologies have been used to screen aptamers, which play an important role in improving the screening efficiency and screening high affinity binding aptamers. This review summarized the screening methods of aptamers through computer-aided sequence evaluation, structural analysis and molecular docking.