Engineering the glycogen metabolism in cyanobacterial photosynthetic cell factories: a review.

Sini Zheng; Huili Sun; Shaoming Mao; Guodong Luan; Xuefeng LÜ

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Engineering the glycogen metabolism in cyanobacterial photosynthetic cell factories: a review.

Author: Sini ZHENG ¹ ; Huili SUN ² ; Shaoming MAO ¹ ; Guodong LUAN ² ; Xuefeng LÜ ²
Author Information

1. College of Life Science and Technology, Central South University of Forestry and Technology, Changsha 410004, Hunan, China.
2. Key Laboratory of Biofuels, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, Shandong, China.
Publication Type:Review
Keywords: cyanobacteria; glycogen; metabolic engineering; photosynthesis; photosynthetic cell factory
MeSH: Carbon/metabolism*; Carbon Dioxide/metabolism*; Cyanobacteria/metabolism*; Glycogen/metabolism*; Metabolic Engineering; Photosynthesis/physiology*
From: Chinese Journal of Biotechnology 2022;38(2):592-604
CountryChina
Language:Chinese
Abstract: Cyanobacteria are important photosynthetic autotrophic microorganisms and are considered as one of the most promising microbial chassises for photosynthetic cell factories. Glycogen is the most important natural carbon sink of cyanobacteria, playing important roles in regulating its intracellular carbon distributions. In order to optimize the performances of cyanobacterial photosynthetic cell factories and drive more photosynthetic carbon flow toward the synthesis of desired metabolites, many strategies and approaches have been developed to manipulate the glycogen metabolism in cyanobacteria. However, the disturbances on glycogen metabolism usually cause complex effects on the physiology and metabolism of cyanobacterial cells. Moreover, the effects on synthesis efficiencies of different photosynthetic cell factories usually differ. In this manuscript, we summarized the recent progress on engineering cyanobacterial glycogen metabolism, analyzed and compared the physiological and metabolism effects caused by engineering glycogen metabolism in different cyanobacteria species, and prospected the future trends of this strategy on optimizing cyanobacterial photosynthetic cell factories.