Microbial synthesis of monoterpenoids: a review.

Fan Zhang; Ying Wang; Chun LI

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Microbial synthesis of monoterpenoids: a review.

Author: Fan ZHANG ¹ ; Ying WANG ¹ ; Chun LI ¹
Author Information

1. Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering, Ministry of Industry and Information Technology, Institute of Biochemical Engineering, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 102488, China.
Publication Type:Review
Keywords: metabolic pathway; microorganism; monoterpenoids; synthetic biology
MeSH: Biosynthetic Pathways; Metabolic Engineering; Monoterpenes/metabolism*; Synthetic Biology; Terpenes
From: Chinese Journal of Biotechnology 2022;38(2):427-442
CountryChina
Language:Chinese
Abstract: Monoterpenoids that belong to the terpenoids family are usually volatile and have strong aroma. Some monoterpenoids also have antioxidant, antibacterial and anti-inflammatory activities, which make them important raw materials for medicine, food and cosmetics industry. In recent years, the heterologous synthesis of monoterpenoids by microorganisms has attracted extensive attention. However, its large-scale application is greatly hampered by the low yield and high production cost. Nowadays, the rapid development of synthetic biology provides new approaches for enhancing the production of monoterpenoids by microorganisms. Different kinds of recombinant strains can be obtained via engineering of microbial cells to produce a variety of monoterpenoids with different properties. This paper summarized the latest strategies and progress in the application of synthetic biology to produce monoterpenoids by microorganisms, including the design and modification of biosynthetic pathway, as well as the design and optimization of high-yield monoterpenoids producing chassis cells.