A Case of Drug Eruption Similar to Erythema Multiforme Induced by Sorafenib.
- Author:
Won Jong OH
1
;
Eun Jung KO
;
Sun Young CHOI
;
Kui Young PARK
;
Kapsok LI
;
Beom Joon KIM
;
Seong Jun SEO
;
Myeung Nam KIM
;
Chang Kwun HONG
Author Information
1. Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea. mnkim@cau.ac.kr
- Publication Type:Case Report
- Keywords:
Drug eruption;
Erythema multiforme;
Sorafenib
- MeSH:
Alopecia;
Carcinoma, Renal Cell;
Cell Proliferation;
Drug Eruptions*;
Erythema Multiforme*;
Erythema*;
Exanthema;
Extremities;
Hemorrhage;
Humans;
Incidence;
Male;
Neoplasm Metastasis;
Skin;
Vasculitis
- From:Korean Journal of Dermatology
2015;53(7):542-545
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Sorafenib is an oral multi-kinase inhibitor with effects on tumor cell proliferation and tumor angiogenesis. The drug is associated with a relatively high incidence of dermatologic adverse events. Frequently observed clinical presentations include skin rash, a hand-foot skin reaction, alopecia, splinter subungual hemorrhages, and xerosis. There have been few reports of erythema multiforme or leukocytoclastic vasculitis related to sorafenib use. We report a case of a 72 year-old male diagnosed with renal cell carcinoma with distant metastasis, who developed an erythema multiforme-like drug eruption on his trunk and extremities after use of sorafenib.
