Influence of Microcirculatory Dysfunction on Myocardial Injury after Cardiopulmonary Resuscitation.
- Author:
Jun YANG
1
;
Gui Juan DONG
1
;
Hong Wei WANG
1
;
Xin ZHAO
1
;
Fu Jun WANG
1
;
Jian ZHANG
1
;
Shu Bin GUO
1
Author Information
- Publication Type:Journal Article
- Keywords: Anisodamine hydrobromide (654-1); Cardiopulmonary resuscitation; Microcirculation dysfunction; Myocardial injury; Post-cardiac arrest syndrome
- MeSH: Animals; Cardiopulmonary Resuscitation; Microcirculation; Swine; Ventricular Fibrillation/therapy*
- From: Biomedical and Environmental Sciences 2022;35(4):334-344
- CountryChina
- Language:English
-
Abstract:
Objective:This study aimed to examine the effects of microcirculatory dysfunction and 654-1 intervention after cardiopulmonary resuscitation on myocardial injury.
Methods:Landrace pigs were divided into a sham operation group (S group, n= 6), ventricular fibrillation control group (VF-C group, n= 8) and 654-1 intervention group (VF-I group, n= 8). Hemodynamics was recorded at baseline, at recovery of spontaneous circulation (ROSC), and 1 h, 2 h, 4 h and 6 h thereafter. Sidestream dark field (SDF) technology was used to evaluate and monitor the microcirculation flow index, total vessel density, perfusion vessel ratio, De-Backer score, and perfusion vessel density in animal viscera at various time points.
Results:After administration of 654-1 at 1.5 h post-ROSC, the hemodynamics in the VF-I group, as compared with the VF-C group, was significantly improved. The visceral microcirculation detected by SDF was also significantly improved in the VF-I group. As observed through electron microscopy, significantly less myocardial tissue injury was present in the VF-I group than the VF-C group.
Conclusion:Administration of 654-1 inhibited excessive inflammatory by improving the state of visceral microcirculation.
