The Use of Lipoprotein-Associated Phospholipase A2 in a Chinese Population to Predict Cardiovascular Events.
- Author:
Hui XI
1
;
Guan Liang CHENG
1
;
Fei Fei HU
2
;
Song Nan LI
3
;
Xuan DENG
2
;
Yong ZHOU
2
Author Information
- Publication Type:Journal Article
- Keywords: All-cause death; Asians; Chinese population; Composite endpoint; Lipoprotein-associated phospholipase A2; Major adverse cardiovascular events; Racial difference; Stroke
- MeSH: 1-Alkyl-2-acetylglycerophosphocholine Esterase/blood*; Asians; Cardiovascular Diseases/diagnosis*; China/epidemiology*; Female; Humans; Longitudinal Studies; Male; Middle Aged; Mortality; Myocardial Infarction/blood*; Predictive Value of Tests; Risk Factors; Stroke/blood*
- From: Biomedical and Environmental Sciences 2022;35(3):206-214
- CountryChina
- Language:English
-
Abstract:
Objective:To explore associations between lipoprotein-associated phospholipase A2 (Lp-PLA2) and the risk of cardiovascular events in a Chinese population, with a long-term follow-up.
Methods:A random sample of 2,031 participants (73.6% males, mean age = 60.4 years) was derived from the Asymptomatic Polyvascular Abnormalities Community study (APAC) from 2010 to 2011. Serum Lp-PLA2 levels were determined by enzyme-linked immunosorbent assay (ELISA). The composite endpoint was a combination of first-ever stroke, myocardial infarction (MI) or all-cause death. Lp-PLA2 associations with outcomes were assessed using Cox models.
Results:The median Lp-PLA2 level was 141.0 ng/mL. Over a median follow-up of 9.1 years, we identified 389 events (19.2%), including 137 stroke incidents, 43 MIs, and 244 all-cause deaths. Using multivariate Cox regression, when compared with the lowest Lp-PLA2 quartile, the hazard ratios with 95% confidence intervals for developing composite endpoints, stroke, major adverse cardiovascular events, and all-cause death were 1.77 (1.24-2.54), 1.92 (1.03-3.60), 1.69 (1.003-2.84), and 1.94 (1.18-3.18) in the highest quartile, respectively. Composite endpoints in 145 (28.6%) patients occurred in the highest quartile where Lp-PLA2 (159.0 ng/mL) was much lower than the American Association of Clinical Endocrinologists recommended cut-off point, 200 ng/mL.
Conclusion:Higher Lp-PLA2 levels were associated with an increased risk of cardiovascular event/death in a middle-aged Chinese population. The Lp-PLA2 cut-off point may be lower in the Chinese population when predicting cardiovascular events.
