Weather and Birth Weight: Different Roles of Maternal and Neonatal <i>GPR61</i> Promoter Methylation.

Zhi Yuan LI; Yong Xiang Gong; Meng Yang; Jian Chai; Ren Jie Sun; Qin Yang LI; Ya Nan HE; Hui Huang; Ya Wei Zhang; Yue BA; Guo Yu Zhou

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Weather and Birth Weight: Different Roles of Maternal and Neonatal GPR61 Promoter Methylation.

Author: Zhi Yuan LI ¹ ; Yong Xiang GONG ¹ ; Meng YANG ¹ ; Jian CHAI ² ; Ren Jie SUN ¹ ; Qin Yang LI ¹ ; Ya Nan HE ¹ ; Hui HUANG ^{3
,

4} ; Ya Wei ZHANG ⁵ ; Yue BA ^{3
,

4} ; Guo Yu ZHOU ^{3
,

4}
Author Information

1. Department of Environmental Health & Environment and Health Innovation Team, School of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China.
2. National Health Commission Key Laboratory of Birth Defects Prevention, Henan Key Laboratory of Population Defects Prevention, Henan Institute of Reproduction Health Science and Technology, Zhengzhou 450002, Henan, China.
3. Department of Environmental Health & Environment and Health Innovation Team, School of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China
4. Yellow River Institute for Ecological Protection & Regional Coordinated Development, Zhengzhou University, Zhengzhou 450001, Henan, China.
5. Department of Environment Health Science, Yale University School of Public Health, New Haven, CT, USA.
Publication Type:Journal Article
Keywords: Birth weight; DNA methylation; GPR61 gene; Mother-newborns; Pregnancy; Weather
MeSH: Air Pollution/analysis*; Birth Weight; Female; Humans; Infant, Newborn; Nerve Tissue Proteins; Pregnancy; Receptors, G-Protein-Coupled/metabolism*; Temperature; Weather
From: Biomedical and Environmental Sciences 2022;35(3):181-193
CountryChina
Language:English
Abstract: Objectives:It is unclear whether G protein-coupled receptor 61 (GPR61) affecting body weight, plays a role in the association between birth weight and weather. This study aimed to assess the effects of prenatal weather and GPR61 on birth weight.
Methods:A total of 567 mother-newborn pairs were recruited in Houzhai Center Hospital during 2011-2012. We detected the maternal and neonatal GPR61 promoter methylation levels, and obtained meteorological and air pollution data.
Results:A positive association was observed between maternal and neonatal GPR61 methylation levels, and both of them were affected by precipitation, relative humidity (RH) and daily temperature range (DTR). Birth weight was associated negatively with RH and positively with DTR ( P < 0.05). A significant association was observed between birth weight and neonatal GPR61 methylation. We observed that maternal GPR61 methylation seemed to modify associations between weather and birth weight ( P _interaction < 0.10), while neonatal GPR61 methylation mediated the effects of RH and DTR on birth weight ( P < 0.05).
Conclusions:Our findings revealed the significant associations among prenatal weather, GPR61 methylation and birth weight. Maternal GPR61 methylation may modify the susceptibility of birth weight to prenatal weather conditions, while neonatal GPR61 methylation may be a bridge of the effects of prenatal RH and DTR on birth weight.