Polymorphisms of the Vitamin D Receptor Gene and Sex-Differential Associations with Lipid Profiles in Chinese Han Adults.

Yan Mei Chen; Ping XU; Zhou Tian Wang; Yu Mei Zhu; Chun Mei Gong; Chang Hua Huang; Xiao Li Liu; Ji Chang Zhou

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Polymorphisms of the Vitamin D Receptor Gene and Sex-Differential Associations with Lipid Profiles in Chinese Han Adults.

Author: Yan Mei CHEN ¹ ; Ping XU ¹ ; Zhou Tian WANG ¹ ; Yu Mei ZHU ² ; Chun Mei GONG ² ; Chang Hua HUANG ³ ; Xiao Li LIU ² ; Ji Chang ZHOU ^{4
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Author Information

1. School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen 518100, Guangdong, China.
2. Shenzhen Center for Chronic Disease Control, Shenzhen 518020, Guangdong, China.
3. Shenzhen Qilinshan Sanatorium, Shenzhen 518055, Guangdong, China.
4. School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen 518100, Guangdong, China
5. Shenzhen Center for Chronic Disease Control, Shenzhen 518020, Guangdong, China
6. Guangdong Province Engineering Laboratory for Nutrition Translation, Guangzhou 510080, Guangdong, China.
Publication Type:Journal Article
Keywords: Dyslipidemia; Gene polymorphism; Lipid; Vitamin D; Vitamin D receptor
MeSH: Adult; Alleles; Asians/genetics*; China/ethnology*; Dyslipidemias/genetics*; Female; Genetic Predisposition to Disease/genetics*; Genotype; Humans; Lipids/blood*; Male; Middle Aged; Polymorphism, Single Nucleotide; Receptors, Calcitriol/genetics*; Sex Factors; Vitamin D/blood*
From: Biomedical and Environmental Sciences 2022;35(2):115-125
CountryChina
Language:English
Abstract: OBJECTIVE:To explore the association of single nucleotide polymorphisms (SNPs) of the vitamin D receptor gene ( VDR) with circulating lipids considering gender differences.
METHODS:Of the Han Chinese adults recruited from a health examination center for inclusion in the study, the circulating lipids, 25-hydroxyvitamin D (25OHD), and other parameters were measured. The VDR SNPs of Cdx2 (rs11568820), Fok1 (rs2228570), Apa1 (rs7975232), and Taq1 (rs731236) were genotyped with a qPCR test using blood DNA samples, and their associations with lipids were analyzed using logistic regression.
RESULTS:In the female participants ( n = 236 with dyslipidemia and 888 without dyslipidemia), multiple genotype models of Fok1 indicated a positive correlation of B (not A) alleles with LDLC level ( P < 0.05). In the male participants ( n = 299 with dyslipidemia and 564 without dyslipidemia), the recessive model of Cdx2 and the additive and recessive models of Fok1 differed ( P < 0.05) between the HDLC-classified subgroups, respectively, and Fok1 BB and Cdx2 TT presented interactions with 25OHD in the negative associations with HDLC ( P < 0.05).
CONCLUSION:In the Chinese Han adults included in the study, the Fok1 B-allele of VDR was associated with higher LDLC in females, and the Fok1 B-allele and the Cdx2 T-allele of VDR were associated with lower HDLC in males. The interaction of VD and Fok1 BB or Cdx2 TT in males synergistically decreased HDLC levels.