Association between Maternal Drug Use and Cytochrome P450 Genetic Polymorphisms and the Risk of Congenital Heart Defects in Offspring.

Jia Bi QIN; Liu LUO; Meng Ting SUN; Peng HUANG; Ting Ting WANG; Sen Mao ZHANG; Jin Qi LI; Yi Huan LI; Le Tao CHEN; Jing Yi DIAO; Ping ZHU

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Association between Maternal Drug Use and Cytochrome P450 Genetic Polymorphisms and the Risk of Congenital Heart Defects in Offspring.

Author: Jia Bi QIN ^{1
,

2
,

3} ; Liu LUO ⁴ ; Meng Ting SUN ⁴ ; Peng HUANG ⁵ ; Ting Ting WANG ³ ; Sen Mao ZHANG ⁴ ; Jin Qi LI ⁴ ; Yi Huan LI ⁴ ; Le Tao CHEN ⁴ ; Jing Yi DIAO ⁴ ; Ping ZHU ⁶
Author Information

1. Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510100, Guangdong, China
2. Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha 410078, Hunan, China
3. NHC Key Laboratory of Birth Defect for Research and Prevention, Hunan Provincial Maternal and Child Health Care Hospital, Changsha 410008, Hunan, China.
4. Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha 410078, Hunan, China.
5. Hunan Children's Hospital, Changsha 410007, Hunan, China.
6. Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510100, Guangdong, China.
Publication Type:Journal Article
Keywords: Case-control study; Congenital heart defect; Cytochrome P450 genes; Maternal drug use
MeSH: Adult; Cytochrome P-450 Enzyme System/genetics*; Female; Genotype; Heart Defects, Congenital/genetics*; Humans; Infant, Newborn; Polymorphism, Genetic; Pregnancy; Pregnancy Complications/drug therapy*
From: Biomedical and Environmental Sciences 2022;35(1):45-57
CountryChina
Language:English
Abstract: OBJECTIVE:This study aimed to assess the associations between maternal drug use, cytochrome P450 ( CYP450) genetic polymorphisms, and their interactions with the risk of congenital heart defects (CHDs) in offspring.
METHODS:A case-control study involving 569 mothers of CHD cases and 652 controls was conducted from November 2017 to January 2020.
RESULTS:After adjusting for potential confounding factors, the results show that mothers who used ovulatory drugs (adjusted odds ratio [a OR] = 2.12; 95% confidence interval [ CI]: 1.08-4.16), antidepressants (a OR = 2.56; 95% CI: 1.36-4.82), antiabortifacients (a OR = 1.55; 95% CI: 1.00-2.40), or traditional Chinese drugs (a OR = 1.97; 95% CI: 1.26-3.09) during pregnancy were at a significantly higher risk of CHDs in offspring. Maternal CYP450 genetic polymorphisms at rs1065852 (A/T vs. A/A: OR = 1.53, 95% CI: 1.10-2.14; T/T vs. A/A: OR = 1.57, 95% CI: 1.07-2.31) and rs16947 (G/G vs. C/C: OR = 3.41, 95% CI: 1.82-6.39) were also significantly associated with the risk of CHDs in offspring. Additionally, significant interactions were observed between the CYP450genetic variants and drug use on the development of CHDs.
CONCLUSIONS:In those of Chinese descent, ovulatory drugs, antidepressants, antiabortifacients, and traditional Chinese medicines may be associated with the risk of CHDs in offspring. Maternal CYP450 genes may regulate the effects of maternal drug exposure on fetal heart development.