Association between the Neutrophil-to-lymphocyte Ratio and New-onset Subclinical Macrovascular and Microvascular Diseases in the Chinese Population.

Jia Lu Wang; Qiu Yu Cao; Zhuo Jun Xin; Shan Shan Liu; Min XU; Tian Ge Wang; Jie Li LU; Yu Hong Chen; Shuang Yuan Wang; Zhi Yun Zhao; Yu XU; Guang Ning; Wei Qing Wang; Yu Fang BI; Mian LI

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Association between the Neutrophil-to-lymphocyte Ratio and New-onset Subclinical Macrovascular and Microvascular Diseases in the Chinese Population.

Author: Jia Lu WANG ^{1
,

2} ; Qiu Yu CAO ^{1
,

2} ; Zhuo Jun XIN ^{1
,

2} ; Shan Shan LIU ^{1
,

2} ; Min XU ^{1
,

2} ; Tian Ge WANG ^{1
,

2} ; Jie Li LU ^{1
,

2} ; Yu Hong CHEN ^{1
,

2} ; Shuang Yuan WANG ^{1
,

2} ; Zhi Yun ZHAO ^{1
,

2} ; Yu XU ^{1
,

2} ; Guang NING ^{1
,

2} ; Wei Qing WANG ^{1
,

2} ; Yu Fang BI ^{1
,

2} ; Mian LI ^{1
,

2}
Author Information

1. Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
2. Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Publication Type:Journal Article
Keywords: Body mass index; Neutrophil-to-lymphocyte ratio; Prospective cohort study; Subclinical macrovascular and microvascular diseases
MeSH: Adult; Aged; Ankle Brachial Index; Body Mass Index; China/epidemiology*; Cohort Studies; Female; Humans; Incidence; Lymphocytes/cytology*; Male; Middle Aged; Neutrophils/cytology*; Poisson Distribution; Prospective Studies; Vascular Diseases/etiology*
From: Biomedical and Environmental Sciences 2022;35(1):4-12
CountryChina
Language:English
Abstract: OBJECTIVE:The association between neutrophil-to-lymphocyte ratio (NLR) with subclinical macrovascular and microvascular diseases has been less investigated. We sought to examine the association between NLR and new-onset subclinical macrovascular and microvascular abnormalities in the Chinese population.
METHODS:From a community cohort, we included 6,430 adults aged ≥ 40 years without subclinical macrovascular and microvascular diseases at baseline. We measured subclinical macrovascular and microvascular abnormalities separately using the ankle-brachial index (ABI), brachial-ankle pulse wave velocity (baPWV), and albuminuria.
RESULTS:During a mean follow-up of 4.3 years, 110 participants developed incident abnormal ABI, 746 participants developed incident elevated baPWV, and 503 participants developed incident albuminuria. Poisson regression analysis indicated that NLR was significantly associated with an increased risk of new-onset abnormal ABI, elevated baPWV, and albuminuria. Compared to overweight/obese participants, we found a much stronger association between NLR and subclinical vascular abnormalities in participants with normal weight. Furthermore, we found an interaction between the NLR and body mass index (BMI) on the risk of new-onset abnormal ABI ( P for interaction: 0.01).
CONCLUSION:NLR was associated with subclinical macrovascular and microvascular diseases in the Chinese population. Furthermore, in participants with normal weight, the association between NLR and subclinical vascular abnormalities was much stronger.