The role of regulated cell death in renal ischemia-reperfusion injury.
- Author:
Xin-Bei LIU
1
;
Wen-Jing LIU
2
Author Information
1. School of Medicine, Yunnan University, Kunming 650091, China.
2. School of Medicine, Yunnan University, Kunming 650091, China. liuwenjing@ynu.edu.cn.
- Publication Type:Review
- MeSH:
Apoptosis;
Ferroptosis;
Humans;
Kidney/metabolism*;
Necroptosis;
Regulated Cell Death;
Reperfusion Injury/drug therapy*
- From:
Acta Physiologica Sinica
2022;74(2):320-332
- CountryChina
- Language:Chinese
-
Abstract:
Renal ischemia-reperfusion injury (IRI) is histologically characterized by tubular cell death. Diverse pathways of regulated cell death (RCD) have been reported to contribute to renal IRI in recent studies. In this review, we discuss the signaling pathways, regulators and crosstalk of RCD, including necroptosis, ferroptosis and pyroptosis, and their role in renal IRI in order to pave the way for new therapeutic opportunities.
