Exercise regulates lipid metabolism via lipophagy and its molecular mechanisms.
- Author:
Meng-Ying LI
1
;
Ling-Jie LI
2
;
Chun-Wei MA
1
;
Bing-Hong GAO
3
Author Information
1. School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China.
2. School of Physical Training, Shanghai University of Sport, Shanghai 200438, China.
3. School of Physical Training, Shanghai University of Sport, Shanghai 200438, China. gaobinghong@126.com.
- Publication Type:Review
- MeSH:
Autophagy/physiology*;
Humans;
Lipid Droplets/metabolism*;
Lipid Metabolism/physiology*;
Liver;
Metabolic Diseases/metabolism*
- From:
Acta Physiologica Sinica
2022;74(2):309-319
- CountryChina
- Language:Chinese
-
Abstract:
Lipophagy is a kind of selective autophagy, which can selectively identify and degrade lipid droplets and plays an important role in regulating cellular lipid metabolism and maintaining intracellular lipid homeostasis. Exercise can induce lipophagy and it is also an effective means of reducing body fat. In this review, we summarized the relationship between exercise and lipophagy in the liver, pancreas, adipose tissue, and the possible molecular mechanisms to provide a new clue for the prevention and treatment of fatty liver, obesity and other related metabolic diseases by exercise.
