Biological function of Nogo-B receptor.
- Author:
Ying ZHU
1
;
Li-Qun ZHANG
1
;
Jian-Dong LI
2
Author Information
1. Department of Respiratory and Critical Care Medicine, Eighth Medical Center of Chinese PLA General Hospital, Beijing 100091, China.
2. Department of Respiratory and Critical Care Medicine, Eighth Medical Center of Chinese PLA General Hospital, Beijing 100091, China. lijdzyy@163.com.
- Publication Type:Journal Article
- MeSH:
Carrier Proteins/metabolism*;
Endoplasmic Reticulum/metabolism*;
Lipid Metabolism;
Nogo Proteins/metabolism*;
Receptors, Cell Surface/metabolism*
- From:
Acta Physiologica Sinica
2022;74(2):301-308
- CountryChina
- Language:Chinese
-
Abstract:
Nogo-B receptor (NgBR) is a specific receptor of Nogo-B, a member of reticulon 4 protein family. It is widely expressed in many tissues and mainly located in cell membrane and endoplasmic reticulum. Previous studies have revealed that NgBR is involved in a variety of physiological and pathophysiological processes, such as dolichol synthesis, lipid metabolism, cholesterol trafficking, insulin resistance, vascular remodeling and angiogenesis, tumorigenesis and nervous system diseases. Further studies on the molecular characteristics and biological function of NgBR might be of great significance to understand its role in diverse diseases and provide possible clinical strategies for the treatment of diseases.
