Histone deacetylases and acute kidney injury.
- Author:
Feng-Chen SHEN
1
;
Shou-Gang ZHUANG
2
,
3
Author Information
1. Department of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China.
2. Department of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China. szhuang@lifespan.org
3. gangzhuang@hotmail.com.
- Publication Type:Review
- MeSH:
Acetylation;
Acute Kidney Injury;
Histone Acetyltransferases/metabolism*;
Histone Deacetylases/metabolism*;
Humans;
Protein Processing, Post-Translational
- From:
Acta Physiologica Sinica
2022;74(1):73-79
- CountryChina
- Language:Chinese
-
Abstract:
Histone acetylation is one of the epigenetic modifications. Histone acetylation, which is catalyzed by histone acetyltransferases and negatively regulated by histone deacetylases, plays an important role in a variety of cellular physiological and pathophysiological processes. Recent studies have shown that histone deacetylases are involved in a variety of pathophysiological responses to acute kidney injury, such as apoptosis, dedifferentiation, proliferation and regeneration. This article reviews the role and underlying mechanism of histone deacetylases in acute kidney injury induced by ischemia reperfusion, nephrotoxicants, sepsis and rhabdomyolysis.
