The renal metabolic mechanism of salt sensitive hypertension in Dahl-SS rats.
- Author:
Meng CHEN
1
;
Peng-Fei YANG
1
;
Zhong-Min TIAN
2
Author Information
1. The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China.
2. The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China. zmtian@mail.xjtu.edu.cn.
- Publication Type:Review
- MeSH:
Animals;
Blood Pressure;
Hypertension;
Kidney/metabolism*;
Rats;
Rats, Inbred Dahl;
Sodium Chloride, Dietary
- From:
Acta Physiologica Sinica
2022;74(1):47-58
- CountryChina
- Language:Chinese
-
Abstract:
The kidney is one of the main target organs involved in hypertension, and it regulates water and salt metabolism, blood volume and vascular resistance. High salt intake induces salt and water retention, persistent endothelial dysfunction and elevation of blood pressure in salt sensitive individuals. Dahl salt sensitive (Dahl-SS) rats, as a classic animal model for salt sensitive hypertension, have many similar stably inherited physiological characteristics to human with salt sensitive hypertension, such as salt sensitivity, hyperlipidemia, insulin resistance, renal failure, increased urinary protein secretion and low plasma renin activity. Based on renal physiology and biochemistry researches and multi-omics analyses in Dahl-SS rats, this review will summarize the relationship between salt sensitive hypertension and renal redox, NO, amino acids, glucose and lipid metabolism.
