Chronic hypoperfusion due to intracranial large artery stenosis is not associated with cerebral β-amyloid deposition and brain atrophy.
10.1097/CM9.0000000000001918
- Author:
Dongyu FAN
1
;
Huiyun LI
1
;
Dongwan CHEN
1
;
Yang CHEN
1
;
Xu YI
1
;
Heng YANG
1
;
Qianqian SHI
1
;
Fangyang JIAO
2
;
Yi TANG
2
;
Qiming LI
2
;
Fangyang WANG
2
;
Shunan WANG
3
;
Rongbing JIN
2
;
Fan ZENG
1
;
Yanjiang WANG
1
Author Information
1. Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, 400042, China.
2. Department of Nuclear Medicine, Daping Hospital, Third Military Medical University, Chongqing, 400042, China.
3. Department of Radiology, Daping Hospital, Third Military Medical University, Chongqing, 400042, China.
- Publication Type:Journal Article
- MeSH:
Aged;
Alzheimer Disease/pathology*;
Amyloid beta-Peptides/metabolism*;
Arteries;
Atrophy;
Brain/metabolism*;
Cerebral Cortex/metabolism*;
Cerebrovascular Circulation;
Constriction, Pathologic/pathology*;
Female;
Humans;
Magnetic Resonance Imaging/methods*;
Male;
Middle Aged;
Positron-Emission Tomography/methods*
- From:
Chinese Medical Journal
2022;135(5):591-597
- CountryChina
- Language:English
-
Abstract:
BACKGROUND:Insufficient cerebral perfusion is suggested to play a role in the development of Alzheimer disease (AD). However, there is a lack of direct evidence indicating whether hypoperfusion causes or aggravates AD pathology. We investigated the effect of chronic cerebral hypoperfusion on AD-related pathology in humans.
METHODS:We enrolled a group of cognitively normal patients (median age: 64 years) with unilateral chronic cerebral hypoperfusion. Regions of interest with the most pronounced hypoperfusion changes were chosen in the hypoperfused region and were then mirrored in the contralateral hemisphere to create a control region with normal perfusion. 11C-Pittsburgh compound-positron emission tomography standard uptake ratios and brain atrophy indices were calculated from the computed tomography images of each patient.
RESULTS:The median age of the 10 participants, consisting of 4 males and 6 females, was 64 years (47-76 years). We found that there were no differences in standard uptake ratios of the cortex (volume of interest [VOI]: P = 0.721, region of interest [ROI]: P = 0.241) and grey/white ratio (VOI: P = 0.333, ROI: P = 0.445) and brain atrophy indices (Bicaudate, Bifrontal, Evans, Cella, Cella media, and Ventricular index, P > 0.05) between the hypoperfused regions and contralateral normally perfused regions in patients with unilateral chronic cerebral hypoperfusion.
CONCLUSION:Our findings suggest that chronic hypoperfusion due to large vessel stenosis may not directly induce cerebral β-amyloid deposition and neurodegeneration in humans.
