Pericarditis and myocarditis after COVID-19 mRNA vaccination in a nationwide setting.
10.47102/annals-acadmedsg.2021425
- Author:
Jonathan YAP
1
;
Mun Yee THAM
;
Jalene POH
;
Dorothy TOH
;
Cheng Leng CHAN
;
Toon Wei LIM
;
Shir Lynn LIM
;
Yew Woon CHIA
;
Yean Teng LIM
;
Jonathan CHOO
;
Zee Pin DING
;
Ling Li FOO
;
Simin KUO
;
Yee How LAU
;
Annie LEE
;
Khung Keong YEO
Author Information
1. Department of Cardiology, National Heart Centre Singapore, Singapore.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
COVID-19/prevention & control*;
COVID-19 Vaccines/adverse effects*;
Child;
Female;
Humans;
Male;
Middle Aged;
Myocarditis/etiology*;
Pericarditis/etiology*;
RNA, Messenger;
SARS-CoV-2;
Vaccination/adverse effects*;
Vaccines, Synthetic;
Young Adult;
mRNA Vaccines
- From:Annals of the Academy of Medicine, Singapore
2022;51(2):96-100
- CountrySingapore
- Language:English
-
Abstract:
INTRODUCTION:Despite reports suggesting an association between COVID-19 mRNA vaccination and pericarditis and myocarditis, detailed nationwide population-based data are sparsely available. We describe the incidence of pericarditis and myocarditis by age categories and sex after COVID-19 mRNA vaccination from a nationwide mass vaccination programme in Singapore.
METHODS:The incidence of adjudicated cases of pericarditis and myocarditis following COVID-19 mRNA vaccination that were reported to the vaccine safety committee between January to July 2021 was compared with the background incidence of myocarditis in Singapore.
RESULTS:As of end July 2021, a total of 34 cases were reported (9 pericarditis only, 14 myocarditis only, and 11 concomitant pericarditis and myocarditis) with 7,183,889 doses of COVID-19 mRNA vaccine administered. Of the 9 cases of pericarditis only, all were male except one. The highest incidence of pericarditis was in males aged 12-19 years with an incidence of 1.11 cases per 100,000 doses. Of the 25 cases of myocarditis, 80% (20 cases) were male and the median age was 23 years (range 12-55 years) with 16 cases after the second dose. A higher-than-expected number of cases were seen in males aged 12-19 and 20-29 years, with incidence rates of 3.72 and 0.98 case per 100,000 doses, respectively.
CONCLUSION:Data from the national registry in Singapore indicate an increased incidence of pericarditis and myocarditis in younger men after COVID-19 mRNA vaccination.
