Effect of Photodynamic Therapy and Intravitreal Triamcinolone Acetonide on Choroidal Neovascularization in Age-related Macular Degeneration.
- Author:
Hyun Sub OH
1
;
Mi In ROH
;
Sang Joon OH
;
Sung Chul LEE
;
Won Young LEE
;
Oh Woong KWON
Author Information
1. The Insitiute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea. owkwon0301@yumc.yonsei.ac.kr
- Publication Type:Original Article
- Keywords:
Age-related macular degeneration;
Choroidal neovascularization;
Intravitreal triamcinolone acetonide;
Photodynamic therapy
- MeSH:
Choroid*;
Choroidal Neovascularization*;
Fluorescein Angiography;
Humans;
Macular Degeneration*;
Macular Edema;
Photochemotherapy*;
Retreatment;
Steroids;
Triamcinolone Acetonide*;
Triamcinolone*;
Visual Acuity
- From:Journal of the Korean Ophthalmological Society
2005;46(8):1321-1327
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To evaluate the safety and visual outcome of intravitreal triamcinolone acetonide combined with photodynamic therapy for subfoveal choroidal neovascularization in patients with age-related macular degeneration. METHODS: We evaluated 32 eyes of 32 patients with choroidal neovascularization due to age-related macular degeneration. The study group received photodynamic therapy and intravitreal triamcinolone acetonide (combined group), while the control group received photodynamic therapy only (PDT group). RESULTS: Three months after treatment, no difference was detected between the two groups in visual acuity changes (p>0.05), but the leakage in fluorescein angiography and macular edema in optical coherent tomography decreased (p<0.05) in the combined group. The retreatment rate in the combined group (6.0%) after 3 months was lower than that of the PDT group (53.3%). CONCLUSIONS: Photodynamic therapy with intravitreal triamcinolone acetonide to choroidal neovascularization reduced the retreatment rate at 3 months significantly. These results may have been be due to the short-term anti-inflammatory effect of steroids.
