Research progress of pharmacokinetic factors of metformin

VernacularTitle:二甲双胍药动学影响因素的研究进展
Author: Yike SHEN ^{1
,

2} ; NIYANGZHUOMA ³ ; Lin HU ^{1
,

2} ; Ningning QIN ^{1
,

2} ; Wenbin LI ¹ ; Anpeng ZHAO ¹ ; Rong WANG ^{1
,

2} ; Yuemei SUN ¹
Author Information

1. Dept. of Pharmacy，No. 940 Hospital of Joint Logistics Support Force of Chinese People’s Liberation Army，Lanzhou 730050，China
2. College of Pharmacy，Lanzhou University，Lanzhou 730020，China
3. Dept. of Internal M edicine，Yushu Bayi Hospital，Qinghai Yushu 815000，China
Publication Type:Journal Article
Keywords: metformin; pharmacokinetics; gene polymorphism; drug interactions; intestinal flora; plateau hypoxia
From: China Pharmacy 2022;33(12):1513-1519
CountryChina
Language:Chinese
Abstract: Metformin is the most common first-line oral hypoglycemic drug ，but there are large individual differences in pharmacokinetic parameters and pharmacodynamics during clinical use. The dosage of some patients should be adjusted to achieve satisfactory therapeutic effect. Pharmacokinetic parameters of metformin are affected by many factors ，including respects of transporter gene polymorphism ，drug interaction ，intestinal flora ，plateau hypoxia and physiological function and so on. In order to guide the clinical individualized use of metformin ，this study reviews the research progress on the influencing factors of metformin pharmacokinetics.