Effect of β- aescine Sodium on Tumor Necrosis Factor α in Severe Traumatic Brain Injury
10.3969/j.issn.1006-9771.2014.03.016
- VernacularTitle:β-七叶皂苷钠对重型脑损伤患者血清肿瘤坏死因子-α的影响
- Author:
Yuanyang DENG
1
;
Haineng HUANG
1
;
Guiyuan WEI
1
;
Huadong HUANG
1
;
Qisheng LUO
1
;
Huangde FU
1
;
Chuanyu LI
1
Author Information
1. Neurosurgery Department, Affiliated Hospital, Youjiang Medical College for Nationality, Baise 533000, Guangxi, China
- Publication Type:Journal Article
- Keywords:
β-aescine sodium, severe traumatic brain injury, tumor necrosis factor α
- From:
Chinese Journal of Rehabilitation Theory and Practice
2014;(3):259-261
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of β-aescine sodium on tumor necrosis factor α (TNF-α) in patient with severe traumatic brain injury and the clinical significance. Methods 60 patients with severe traumatic brain injury were divided equally into control group (n=30) and treatment group (n=30), who accepted routine therapy and further β-aescine sodium respectively. The serum TNF-α was determined before and 1 d, 2 d, 3 d, 5 d and 7 d after treatment. The patients were assessed with Glasgow Outcome Scale (GOS) 3 months after treatment.Results There was significant difference of serum TNF-α between treatment group and control group since 3 d after treatment (P<0.05). The score of GOS was better in the treatment group than in the control group 3 months after treatment (P<0.05). Conclusion β-aescine sodium is effective on severe traumatic brain injury. Level of TNF-α may be related with the outcome of patients with severe traumatic brain injury.
