Role of T cells in ischemic acute kidney injury and repair
- Author:
Kyungho LEE
1
;
Hye Ryoun JANG
Author Information
- Publication Type:1
- From:The Korean Journal of Internal Medicine 2022;37(3):534-550
- CountryRepublic of Korea
- Language:English
- Abstract: Ischemic acute kidney injury (AKI) is a common medical problem with significant mortality and morbidity, affecting a large number of patients globally. Ischemic AKI is associated with intrarenal inflammation as well as systemic inflammation; thus, the innate and adaptive immune systems are implicated in the pathogenesis of ischemic AKI. Among various intrarenal immune cells, T cells play major roles in the injury process and in the repair mechanism affecting AKI to chronic kidney disease transition. Importantly, T cells also participate in distant organ crosstalk during AKI, which affects the overall outcomes. Therefore, targeting T cell-mediated pathways and T cell-based therapies have therapeutic promise for ischemic AKI. Here, we review the major populations of kidney T cells and their roles in ischemic AKI.
