The Clinical Value of p53, c-erbB-2 and Ki-67 Expression in Gallbladder Carcinoma.
- Author:
Kee Hwan KIM
1
;
Sung Ho CHOI
;
Chang Hyeok AHN
;
Jeong Soo KIM
;
Hae Myung JEON
;
Eun Jung LEE
;
Keun Woo LIM
Author Information
1. Department of Surgery, Uijongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Uijongbu, Korea.
- Publication Type:Original Article
- Keywords:
Gallbladder cancer;
p53;
c-erbB-2;
Ki-67;
Immunohistochemical staining
- MeSH:
Formaldehyde;
Gallbladder Neoplasms;
Gallbladder*;
Humans;
Incidence;
Paraffin;
Survival Rate
- From:Journal of the Korean Surgical Society
2001;60(6):649-655
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: We evaluated the correlation between clinicopathologic features and p53, c-erbB-2 and Ki-67 protein expression in gallbladder carcinoma. METHODS: From Jan. 1994 to July 1999, thirty-four cases of gallbladder carcinoma were enrolled in this study and their clinicopathologic findings were analyzed. We performed p53, c-erbB-2, and Ki-67 immunohistochemical staining on formalin fixed, paraffin embedded histological sections with an antibody. RESULTS: The rate of overexpression of p53, c-erbB-2, and Ki-67 protein in gallbladder carcinoma was 47.1%, and 70.6%, 55.9%, respectively. The five year patient survival rate was significantly correlated only with tumor stage; the rate being 64.7% (P=0.031) with p53-negative tumors and 59.0% (P=0.023) with c-erbB-2-positive tumors. CONCLUSION: Progressively increasing incidence of p53, c-erbB-2 and Ki-67 protein overexpression was observed in gallbladder carcinoma patients. Although this study found no correlation between the molecular markers and survival, further study will be needed to evaluate the significance of p53, c-erbB-2 and Ki-67 proteins as prognostic factors.
