A Case of Adult Type Colonic Hypoganglionosis.
- Author:
Joong Goo KWEON
1
;
Eun Young KIM
;
Chang Hyeong LEE
;
Ho Gak KIM
;
Jyung Dong BAE
;
Han Il LEE
;
Chang Ho CHO
;
Hyun Soo KIM
Author Information
1. Department of Internal Medicine, Daegu Catholic University, College of Medicine and Catholic Medical Center, Daegu, Korea. Kwonjg@cuth.cataegu.ac.kr
- Publication Type:Case Report
- Keywords:
Hypoganglionosis;
Colon
- MeSH:
Adult*;
Biopsy;
Colon*;
Constipation;
Diagnosis;
Enteric Nervous System;
Ganglia;
Humans;
Ileus;
Neurons
- From:Korean Journal of Gastrointestinal Endoscopy
2002;24(4):225-229
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Hypoganglionosis is a rare form of intestinal neuronal malformation, which is characterized by scarce ganglia and a reduced number of parasympathetic nerves in the intestinal wall. The pathogenesis of intestinal neuronal malformation is mainly attributed to developmental disorders of the enteric nervous system (ENS). Furthermore, the ENS can be damaged during the postnatal period by ischemic, inflammatory, autoimmunological process or neurotoxic agents. Subsequently abnormalties of the ENS may cause chronic constipation or ileus. Intestinal neuronal malformation should be suspected in patients with a history of chronic stool retention and appropriate radiographic findings. Hypoganglionosis is extremely difficult to establish the diagnosis histochemically unless full-thickness biopsies are performed. Recently we experienced a case of adult type hypoganglionosis, which is assumed to be an acquired type. It was treated with right hemicolectomy.
