Transient Mutism Related to Capecitabine-Induced Acute Toxic Leukoencephalopathy

Author: Hyung Ho KIM ¹ ; Hyunji KIM ; Sumin KIM ; Soo-Hyun KIM ; Geon Ha KIM
Author Information

1. Department of Neurology, Ewha Womans University Mokdong Hospital, College of Medicine, Ewha Womans University, Seoul, Korea
Publication Type:Case Report
From:Journal of the Korean Neurological Association 2022;40(2):172-175
CountryRepublic of Korea
Language:Korean
Abstract: Capecitabine, a precursor of 5-fluorouracil (5-FU), is a well-tolerated and safe chemotherapy that has been used to treat breast, pancreatic, and colorectal cancers. Albeit rare, both 5-FU and capecitbine have been reported to be associated with acute central nervous system toxicity, including cerebellar dysfunction, posterior reversible encephalopathy syndrome, and transient leukoencephalopathies. Here we present a case of 32-year-old female, demonstrating transient mutism related to capecitabine induced acute toxic leukoencephalopathy.