Autoimmune Hepatitis Following Vaccination for SARS-CoV-2 in Korea:Coincidence or Autoimmunity?
10.3346/jkms.2022.37.e116
- Author:
Seong Hee KANG
1
;
Moon Young KIM
;
Mee Yon CHO
;
Soon Koo BAIK
Author Information
1. Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea
- Publication Type:Case Report
- From:Journal of Korean Medical Science
2022;37(15):e116-
- CountryRepublic of Korea
- Language:English
-
Abstract:
Autoimmune hepatitis (AIH) is a chronic, autoimmune disease of the liver that occurs when the body’s immune system attacks liver cells, causing the liver to be inflamed. AIH is one of the manifestations of a coronavirus disease 2019 (COVID-19), as well as an adverse event occurring after vaccination against severe acute respiratory syndrome coronavirus 2 (SARSCoV-2). Few cases of AIH have been described after vaccination with two messenger RNA (mRNA)-based vaccines—BTN162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna)—against SARS-CoV-2. Herein, we report a case of AIH occurring after Pfizer-BioNTech COVID-19 vaccine. A 27-year-old female presented with jaundice and hepatomegaly, appearing 14 days after receiving the second dose of Pfizer-BioNTech vaccine. Her laboratory results showed abnormal liver function with high total immunoglobulin G level. She was diagnosed with AIH with histologic finding and successfully treated with oral prednisolone. We report an AIH case after COVID-19 vaccination in Korea.
