Analysis of Outcomes after Curative Resection of Ampullary Carcinoid Tumor.
- Author:
Sea Hyun KWON
1
;
Shin HWANG
;
Sung Gyu LEE
;
Young Joo LEE
;
Duck Jong HAN
;
Kwang Min PARK
;
Song Cheol KIM
;
Je Ho RYU
;
Jeong Ik PARK
;
Hyo Jun LEE
Author Information
1. Department of Surgery, Asan Medical Center, Ulsan University College of Medicine, Seoul, Korea. shwang@amc.seoul.kr
- Publication Type:Original Article
- Keywords:
Ampullary carcinoid;
carcinoid tumor;
neuroendocrine carcinoma
- MeSH:
Carcinoid Tumor*;
Carcinoma, Neuroendocrine;
Disease-Free Survival;
Humans;
Intention;
Male;
Pancreaticoduodenectomy;
Prognosis;
Recurrence;
Retrospective Studies;
Risk Factors;
Synaptophysin
- From:Korean Journal of Hepato-Biliary-Pancreatic Surgery
2007;11(4):64-68
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Ampullary carcinoid tumors are rare and therefore the clinicopathologic characteristics and prognosis after radical surgery have yet to be clarified. The goal of this study was to analyze the outcome of ampullary carcinoid tumors in patients who underwent radical curative resection. METHODS: From January 1998 to December 2005, 10 patients (3.4%) were diagnosed with an ampullary carcinoid tumor among 294 patients who underwent pancreatoduodenectomy for various ampullary neoplasms. The clinical findings from these 10 patients were retrospectively analyzed. RESULTS: The mean patient age was 58.0 +/- 13.4 years and seven were male. A standard pancreatoduodenectomy was performed in three patients and pylorus-preserving pancreatoduodenectomy in seven. An R0 resection was achieved in all 10 patients. The mean tumor size was 2.1 +/- 1.3 cm. Synaptophysin staining was positive in 10 and chromogranin staining was positive in eight patients. The overall and disease-free survival rates were 90% and 80% at 1 year and 64% and 56% at 3 years, respectively. Univariate analyses revealed that a maximum tumor diameter > or = 2 cm and tumor invasion beyond the ampulla were significant risk factors for tumor recurrence. CONCLUSIONS: The results of this study showed that performing a radical resection is the treatment of choice, with the intention of total tumor removal and the possibility of cure.