Ethanol Extract of Chaenomeles sinensis Inhibits the Development of Benign Prostatic Hyperplasia by Exhibiting Anti-oxidant and Anti-inflammatory Effects
10.15430/JCP.2022.27.1.42
- Author:
Jong Su KANG
1
;
Xin Yi ZHAO
;
Jeong Ho LEE
;
Jeong-Sang LEE
;
Young-Sam KEUM
Author Information
1. College of Pharmacy and Integrated Research Institute for Drug Development, Dongguk University, Goyang, Korea
- Publication Type:Original Article
- From:Journal of Cancer Prevention
2022;27(1):42-49
- CountryRepublic of Korea
- Language:English
-
Abstract:
Chaenomeles sinensis is known to inhibit the development and progression of many age-related diseases, but the underlying molecular mechanisms are largely unclear. In the present study, we observed that the ethanol extract of Chaenomeles sinensis scavenged 2,2’-diphenylpicrylhydrazyl and 2,2’-azinobis diammonium radicals in vitro. The ethanol extract of Chaenomeles sinensisactivated antioxidant response element-luciferase activity and induced expression of NRF2 target genes in HaCaT cells. The ethanol extract of Chaenomeles sinensis also suppressed LPS-induced expression of COX-2 and iNOS proteins, and mRNA expression of TNF-α and IL-2 in RAW264.7 cells. Finally, the ethanol extract of Chaenomeles sinensis significantly suppressed testosterone propionate-induced benign prostatic hyperplasia in mice. Together, our study provides the evidence that the ethanol extract of Chaenomeles sinensis inhibits the development of benign prostatic hyperplasia by exhibiting anti-oxidant and anti-inflammatory effects.
