Research advances in animal models of Wilson's disease
10.3969/j.issn.1001-5256.2022.05.041
- VernacularTitle:肝豆状核变性动物模型的研究进展
- Author:
Yulong YANG
1
;
Taohua WEI
2
;
Wenming YANG
2
,
3
;
Wenjie HAO
1
;
Yue YANG
1
;
Nannan QIAN
1
;
Xiang LI
2
;
Hailin JIANG
2
Author Information
1. Graduate School of Anhui University of Chinese Medicine, Hefei 230000, China
2. Encephalopathy Center, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230000, China
3. Key Laboratory of Xin'an Medicine, Ministry of Education, Hefei 230000, China
- Publication Type:Reviews
- Keywords:
Hepatolenticular Degeneration;
Liver Diseases;
Disease Models, Animal
- From:
Journal of Clinical Hepatology
2022;38(5):1169-1174
- CountryChina
- Language:Chinese
-
Abstract:
Wilson's disease (WD) is a rare autosomal recessive disorder with a complex pathogenesis involving multiple systems, multiple visceral organs, and the complex copper homeostasis regulation system within the body. The liver is the most common organ for copper deposition, and liver injury is the earliest and most common manifestation of WD; therefore, it is important to find an ideal animal model for WD research. By summarizing the animal models of WD commonly used in the world, this article systematically summarizes the background, liver and nervous manifestations, and application of different models and compares the characteristics of different animal models, so as to provide a reference for the application of various animal models of WD.
