Mechanism of ferroptosis in the formation of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis
10.3969/j.issn.1001-5256.2022.05.037
- VernacularTitle:铁死亡的发生机制及其在非酒精性脂肪性肝病/非酒精性脂肪性肝炎发生发展中的作用
- Author:
Minghao LIU
1
;
Sutong LIU
1
;
Lihui ZHANG
1
;
Yajiao GU
1
;
Dongfang SHANG
1
;
Zhun XIAO
1
;
Wenxia ZHAO
1
Author Information
1. Department of Hepatology and Spleen-Stomach, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450000, China
- Publication Type:Reviews
- Keywords:
Non-alcoholic Fatty Liver Disease;
Iron Death;
Lipid Peroxidation
- From:
Journal of Clinical Hepatology
2022;38(5):1152-1155
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis is a type of iron-dependent cell death driven by lipid peroxidation, and its mechanism is associated with iron homeostasis imbalance, lipid peroxidation, and slC7A11-GSH-GPX4 antioxidant system. Ferroptosis plays a key role in the development and progression of nonalcoholic fatty liver disease (NAFLD)/nonalcoholic steatohepatitis (NASH), and inhibition of ferroptosis can almost completely inhibit the development of NASH. This article reviews the research advances in the mechanism of ferroptosis and its role in NAFLD/NASH and proposes the research strategies and technical means for ferroptosis, so as to provide a reference for research on the mechanism of NAFLD/NASH.
