Advances of synthetic biology of flavonoids
10.16438/j.0513-4870.2022-0008
- VernacularTitle:黄酮类化合物合成生物学研究进展
- Author:
Chun-cao LIN
;
Da-wei CHEN
;
Jun-gui DAI
- Publication Type:Research Article
- Keywords:
flavonoids;
synthetic biology;
biosynthetic pathway;
cell factory;
metabolic bottleneck
- From:
Acta Pharmaceutica Sinica
2022;57(5):1322-1335
- CountryChina
- Language:Chinese
-
Abstract:
Flavonoids is one of the biggest families of the plant-derived secondary metabolites with structural diversity. Until now, over 10 000 kinds of flavonoids with distinct structures have been purified and identified from plants, and some of them possess a range of important pharmacological effects, such as anticancer, anti-inflammatory and so on. So far, a number of genes and enzymes responsible for the biosynthesis of flavonoids have been reported, especially, a great of progress has been achieved in the synthetic biology of flavonoids in the recent years. Herein, based upon a brief introduction on the biosynthesis of flavonoids, this review summarizes the research advances in synthetic biology of flavonoids in the past two decades (2001-2021), highlighting the cell factories construction of the representative flavonoids. And, a brief discussion and prospects of the relevant metabolic bottlenecks and optimizing strategies are proposed.
