Universal strategies and methodologies in broad-spectrum antiviral drug discovery
10.16438/j.0513-4870.2021-1783
- VernacularTitle:浅谈广谱抗病毒药物研发的普适性策略
- Author:
Shu-jing XU
;
Dang DING
;
Xin-yong LIU
;
Peng ZHAN
- Publication Type:Research Article
- Keywords:
virus;
broad-spectrum antiviral drug;
inhibitor;
rug design;
medicinal chemistry
- From:
Acta Pharmaceutica Sinica
2022;57(5):1289-1300
- CountryChina
- Language:Chinese
-
Abstract:
Virus infection is a serious threat to human health and social development. The increase in pandemics caused by emerging and re-emerging viruses highlights the urgent need for broad-spectrum antivirals. In this perspective, we highlight recent case studies and summarize the universal strategies and methodologies in broad-spectrum antiviral drug discovery from common targets, common steps in viral life cycle, universal strategies, and broad-spectrum molecules, hoping to provide valuable guidance for the current and future development of antiviral drugs.
