Research progress on improvement of functions of small molecular compounds of traditional Chinese medicine based on supramolecular properties of hyaluronic acid
10.16438/j.0513-4870.2021-1222
- VernacularTitle:基于透明质酸超分子特性对中药小分子化合物功能改进的研究进展
- Author:
Zhi-hua YUAN
1
;
You-ting LIU
2
;
Zhao-hui QU
3
;
Xian-rong QIU
4
;
Zhi-jia WANG
1
;
Wen-min PI
1
;
Xiao-yu LIN
1
;
Peng-long WANG
1
Author Information
1. Department of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 102488, China
2. Taihe Kangmei Chinese Medicine Research Institute Co., Ltd., Beijing 102400, China
3. Zhiran Tiancheng Biotechnology Co., Ltd., Beijing 101299, China
4. Beijing Oriental Miaosen Biotechnology Co., Ltd., Beijing 101299, China
- Publication Type:Research Article
- Keywords:
hyaluronic acid;
supramolecular chemistry;
traditional Chinese medicine;
small molecular product;
functional property
- From:
Acta Pharmaceutica Sinica
2022;57(5):1245-1251
- CountryChina
- Language:Chinese
-
Abstract:
Hyaluronic acid is widely used in biomaterials, cosmetics, clinical medicine and other fields due to its good biocompatibility, degradability, hydrophilicity, tumor targeting, viscosity and other characteristics. Pharmacodynamic activities of natural small molecular products which derived from traditional Chinese medicine (TCM) are significant, but their low solubility and poor targeting limit the clinical application. Based on supramolecular properties of hyaluronic acid, in this review, numerous studies were reviewed on the improvement of solubility, bioavailability, targeting and suitable dosage forms of small molecular compounds in TCM by domestic and foreign scholars using hyaluronic acid as carrier. It provides new ideas and inspirations for exploring the potential application value of small molecule compounds in TCM and even for the research and development of new drugs.
