Indoleamine 2, 3-dioxygenase: An important medium with the role of a double-edged sword in various liver diseases
10.3969/j.issn.1001-5256.2022.06.046
- VernacularTitle:吲哚胺2, 3-双加氧酶——多种肝病中发挥双刃剑作用的重要介质
- Author:
Sen YE
1
;
Hongbin WANG
2
;
Yong FU
3
Author Information
1. Graduate School of Qinghai University, Xining 810016, China
2. Department of Hepatopancre-atobiliary Surgery, The Affiliated Hospital of Qinghai University, Xining 810001, China
3. Qinghai Academy of Animal Husbandry and Veterinary Sciences, Xining 810016, China
- Publication Type:Reviews
- Keywords:
Liver Diseases;
Indoleamine 2, 3-Dioxygenase;
Immune System Phenomena
- From:
Journal of Clinical Hepatology
2022;38(6):1440-1444
- CountryChina
- Language:Chinese
-
Abstract:
Indoleamine 2, 3-dioxygenase (IDO) is an important immunoregulatory enzyme, which can degrade the level of the mammalian essential amino acid tryptophan (TRP), catalyze the initiation and rate-limiting steps through the kynurenine pathway, and produce a variety of metabolites to participate in the immune response. On the one hand, IDO plays an immunosuppressive role in microenvironment and thus leads to infection and immune escape of tumor cells; on the other hand, IDO also exerts an inhibitory effect on the pathogens such as bacteria and parasites and thus protects the body from the harm of pathogens to a certain extent. Therefore, IDO is considered an important medium with the role of a double-edged sword in the development and progression of various liver diseases. This article reviews the latest research advances in IDO in viral hepatitis, liver fibrosis, liver cirrhosis, liver cancer, and hepatic echinococcosis.
