Role of platelets in the development and progression of hepatocellular carcinoma

Xiao YU; Guobing WU; Aibin Zhang; Xiaolong Cheng; Min Liu; Zenan HU; Ya Zheng; Yuping Wang; Zhaofeng Chen

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Role of platelets in the development and progression of hepatocellular carcinoma

VernacularTitle:血小板在肝细胞癌发生发展中的作用
Author: Xiao YU ^{1
,

2} ; Guobing WU ^{1
,

2} ; Aibin ZHANG ^{1
,

2} ; Xiaolong CHENG ^{1
,

2} ; Min LIU ² ; Zenan HU ² ; Ya ZHENG ² ; Yuping WANG ² ; Zhaofeng CHEN ²
Author Information

1. The First Clinical Medical College of Lanzhou University, Lanzhou 730000, China
2. Department of Gastroenterology, The First Hospital of Lanzhou University, Key Laboratory of Gastrointestinal Diseases of Gansu Province, Lanzhou 730000, China
Publication Type:Reviews
Keywords: Carcinoma, Hepatocellular; Blood Platelets; Tumor Microenvironment; Exosomes; Molecular Targeted Therapy
From: Journal of Clinical Hepatology 2022;38(6):1426-1430
CountryChina
Language:Chinese
Abstract: Hepatocellular carcinoma is one of the common causes of tumor-related death, and it has high morbidity and mortality rates in China. Recent studies have shown that platelets are closely associated with the development of hepatocellular carcinoma. Literature review shows that platelets not only participate in hemostasis, but also act on liver cells and tumor microenvironment, promote the formation of new blood vessels, and participate in the development and progression of hepatocellular carcinoma as a cell mediator through immune response and other pathways. In addition, platelets and their derivatives can be used as potential therapeutic targets for hepatocellular carcinoma. Therefore, antiplatelet therapy is expected to become a new adjuvant strategy for the treatment of hepatocellular carcinoma, which has important clinical significance.