Effects of bone marrow mesenchymal stem cells derived exosomes on spinal cord injured animals: a systematic review
10.3969/j.issn.1006-9771.2022.05.014
- VernacularTitle:骨髓间充质干细胞衍生外泌体对脊髓损伤动物治疗作用的系统综述
- Author:
Juanfang WEI
1
;
Linjie WANG
2
;
Yanru CUI
1
;
Qiuyu CEN
1
;
Anren ZHANG
3
Author Information
1. College of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610075, China
2. School of Medicine, Southwest Jiaotong University, Chengdu, Sichuan 610031, China
3. Department of Rehabilitation Medicine, Shanghai Fourth People's Hospital Affiliated to Tongji University, Shanghai 200434, China
- Publication Type:Journal Article
- Keywords:
spinal cord injury;
exosomes;
bone marrow mesenchymal stem cells;
animal experiment;
systematic review
- From:
Chinese Journal of Rehabilitation Theory and Practice
2022;28(5):585-592
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo systematically review the efficacy and safety of exosomes derived from bone marrow mesenchymal stem cells (BMSC) on animal models of spinal cord injury. MethodsAnimal studies about BMSC-derived exosomes for spinal cord injury were retrieved from databases of PubMed, Cochrane Library, Web of Science, CNKI and Wangfang Data, from establishment to October, 2021. Two researchers independently screened and extracted the data, and evaluated the risk of bias. The studies were qualitatively analyzed. ResultsA total of 21 studies were included, involving 1 342 animals. Male or female Sprague-Dawley rats were selected for 18 studies, and the body mass of the rats was (200±50) g in 19 studies. The injury nodes focused on T9-11 spinal cord, with various methods. The types, medication time, frequency, concentration and dose of the exosomes were heterogeneous. ConclusionsThe BMSC-derived exosomes can improve the motor function after spinal cord injury, reduce the damage of spinal cord, resist apoptosis and inflammation, reduce the permeability of blood-spinal cord barrier, and promote the growth of axons and blood vessels. More high-quality studies are needed for further verification.
