Effects of exercise intervention on fatigue for patients with multiple sclerosis: a meta-analysis
10.3969/j.issn.1006-9771.2022.05.012
- VernacularTitle:运动干预对多发性硬化患者疲劳症状影响的Meta分析
- Author:
Zhen XU
1
;
Yidi WANG
2
;
Yue ZHANG
3
;
Yuhong WEN
4
Author Information
1. Department of Physical Education, Nankai University, Tianjin 300071, China
2. China Swimming College, Beijing Sport University, Beijing 100084, China
3. Department of Physical Education, Shanghai Jiao Tong University, Shanghai 200240, China
4. School of Recreational Sports and Tourism, Beijing Sport University, Beijing 100084, China
- Publication Type:Journal Article
- Keywords:
multiple sclerosis;
exercise;
fatigue;
meta-analysis
- From:
Chinese Journal of Rehabilitation Theory and Practice
2022;28(5):568-577
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo evaluate the effect and safety of exercise intervention on fatigue for patients with multiple sclerosis (MS). MethodsRandomized controlled trials (RCT) about effect of exercise intervention on MS fatigue were retrieved from the databases of PubMed, Cochrane Central Register of Controlled Trails, Web of Science, CNKI and Wanfang Data from establishment to June, 2021. Two researchers independently screened the literature, extracted the data and assessed the quality of eligible studies. Meta-analysis was performed with Stata 16.0. ResultsA total of 41 RCT with 2 155 patients were included. Compared with control group, exercise intervention might improve the MS fatigue at the end of intervention in exercise group (SMD = -0.59, 95%CI -0.73 to -0.44, P < 0.001). There was no significant difference between the exercise group and the control group in follow-up period (SMD = -0.07, 95%CI -0.26 to 0.12, P = 0.47). Exercise intervention did not increase the recurrence of MS (RR = 0.67, 95%CI 0.45 to 1.00, P = 0.06). ConclusionExercise intervention can effectively relieve the fatigue of MS without increasing the recurrence of MS.
